07-P017 Sumoylation modulates Spalt activity

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07-P017 Sumoylation modulates Spalt activity

embryogenesis, the ventral telencephalon (VT) plays a major role in the early development of these tracts. First, two populations of pioneer neurons allow corticothalamic (CTA) and thalamocortical axons (TCA) to enter the VT. Secondly, the VT forms a permissive corridor which guides TCAs through the MGE. Finally, thalamortical and corticothalamic axons guide each other once they have met in the...

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Sumoylation modulates the activity of Spalt-like proteins during wing development in Drosophila.

The Spalt-like family of zinc finger transcription factors is conserved throughout evolution and is involved in fundamental processes during development and during embryonic stem cell maintenance. Although human SALL1 is modified by SUMO-1 in vitro, it is not known whether this post-translational modification plays a role in regulating the activity of this family of transcription factors. Here,...

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SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner

Androgen receptor (AR) plays an important regulatory role in prostate cancer. AR's transcriptional activity is regulated by androgenic ligands, but also by post-translational modifications, such as SUMOylation. To study the role of AR SUMOylation in genuine chromatin environment, we compared androgen-regulated gene expression and AR chromatin occupancy in PC-3 prostate cancer cell lines stably ...

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SUMOylation modulates the function of Aurora-B kinase.

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Endocytosis defines the entry of molecules or macromolecules through the plasma membrane as well as membrane trafficking in the cell. It depends on a large number of proteins that undergo protein-protein and protein-phospholipid interactions. EH Domain containing (EHDs) proteins formulate a family, whose members participate in different stages of endocytosis. Of the four mammalian EHDs (EHD1-EH...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2009

ISSN: 0925-4773

DOI: 10.1016/j.mod.2009.06.300